2 edition of influence of lifelong exposure to environmental fluoride on bone quality in humans. found in the catalog.
influence of lifelong exposure to environmental fluoride on bone quality in humans.
Written in English
|The Physical Object|
|Number of Pages||289|
“Trace elements are known to influence bone metabolism; however, their effects may be exacerbated in renal failure because dialysis patients are unable to excrete excess elements properly. Our study correlated bone quality in dialysis patients with levels of bone fluoride, magnesium, and aluminum. However, after long-term exposure to high fluoride content in food or water, the thyroid glands of some animals have been found to contain increased fluoride levels (EFSA ). Human Studies There are limited data on neurotoxicity of fluoride in humans. It has been demonstrated that degenerative changes in the central nervous system.
2. Environmental occurrence, geochemistry and exposure 5 Fluoride distribution in water 6 Exposure 8 Air 8 Dental products 8 Food and beverages other than water 8 Water 22 Total fluoride exposure 24 References 24 3. Human health effects 29 Fluoride metabolism 29 Absorption 29 Distribution Introduction. Community water, salt, milk, and dental products have been fluoridated in varying degrees for more than 60 y to prevent dental caries, while fluoride supplementation has been recommended to prevent bone fractures (Jones et al. ).In addition, people may be exposed to fluoride through the consumption of naturally contaminated drinking water, dietary sources, dental products Cited by:
It is now well established from clinical trials, animal studies, and in-vitro studies that fluoride exposure can weaken bone. The mechanisms by which fluoride exposure reduces bone strength are also well known. The matter that remains in controversy is the level of fluoride in drinking water that places society, or susceptible subsets of society, at risk for weakened bones and fracture. Fluoride indeed increases bone mineral density, up to a point -- but high doses makes bones more brittle, says Connett, a professor of environmental chemistry and toxicology at Author: Jeanie Lerche Davis.
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The objective of this study was to determine if lifelong exposure to environmental sources of fluoride (including fluoridated water) had an effect on bone quality in humans. Ninety-two femoral heads were obtained from individuals undergoing total hip arthroplasty in regions with and without fluoridated water (Toronto and Montreal, respectively), so that the donors would have had a wide range of fluoride exposure.
The US Environmental Protection Agency, in a dose-response analysis of the effects of ingested fluoride on severe dental fluorosis and bone structure, estimated that the reference dose (RfD) for fluoride intake from non-therapeutic sources such as diet and drinking water is approximately 6 mg/day for a person weighing 70 kg, based on mg fluoride per kg per day (US Environmental Protection Cited by: This situation has led to a controversy in assessing the impact of environmental fluoride exposure and the health effects in some places [18, 19].
Therefore, this study was aimed to establish the. effect of fluoride exposure on thyroid function. It is difficult to predict exactly what effects on thyroid function are likely at what concentration of fluoride exposure and under what circumstances. In humans, effects on thyroid function were associated with fluoride exposures of File Size: KB.
Bone Response to Fluoride Exposure Is Influenced by Genetics Article (PDF Available) in PLoS ONE 9(12):e December with 87 Reads How we measure 'reads'. 99% of this fluoride resides in the bone,39 where it is incorporated into the crystalline structure and accumulates over time Thus, the teeth and bones are tissues of the body that concentrate the fluoride to which we are exposed.
Exposure to excess fluoride can result in dental fluorosis, a condition in which the teeth enamel becomes irreversiblyFile Size: KB.
Introduction. Fluoride (F −) is a trace element that is incorporated into bone mineral during bone de substitutes for the hydroxyl group in hydroxyapatite, forming fluorapatite. The action of fluoride on bone has been extensively studied and this ion has been shown to have an effect on bone mineral, bone cells and bone by: Among the different source of fluoride, drinking water is the most common source of exposure of fluoride in humans.
Consumption of excess fluoride through water can lead to dental, skeletal and non-skeletal fluorosis. Brick tea-type by: Fluoride had a positive effect on bone strength for lower fluoride intakes and a negative influence on bone strength for higher fluoride intakes.
The vertebral fluoride content at which femoral strength was maximum was between 1, and 1, ppm. Questions and Answers on Fluoride The U.S. Environmental Protection Agency today announced that it has reevaluated the current science on fluoride. EPA will rely on these new assessments to review the existing maximum level of fluoride allowed in drinking water and determine whether its drinking water regulations for fluoride should be revised.
Chronic environmental fluoride exposure under calcium stress causes fragility fractures due to osteoporosis and bone quality deterioration, at least in sheep. Proof of skeletal fluorosis, presenting without increased bone density, calls for a review of fracture incidence in areas with fluoridated groundwater, including an analysis of patients with low bone by: Fluoride has an important role in bone mineralization and formation of dental enamels.
Fluoride, when consumed in inadequate quantities (less than ppm), causes health problems such as dental caries, lack of formation of dental enamel, and reduced bone mineralization, especially among children (WHO ).Cited by: Our results suggest that serum fluoride and urinary fluoride can be used as reference indications to provide an overall reflection of the body’s fluoride-load and fluoride exposure level.
Serum ALP activity and serum BGP content can be used as important reference indications for diagnosing bone metabolism changes resulting from fluoride by: Introduction. Fluoride (F) is readily absorbed from the stomach and small intestine, followed by its deposition in calcified tissues and urinary anabolic effect of F on bone mass has been studied for many years, but there is still controversy about the quality of the bone formed.Evaluation of the efficacy of F therapy is complicated, since it can have a biphasic dose.
Her PhD on the influence of fluoride on bone quality was supervised by Marc Grynpas in the Department of Materials at Toronto. She studied Colletes bees, which create a cellophane-like substance to wrap their eggs in tunnels. [clarification needed] The bees first create fibres of silk, followed by layers of plastics.
Career and researchAlma mater: University of Toronto (BS, MA, PhD). Effect of Long-Term Exposure to Fluoride in Drinking Water on Risks of Bone Fractures YIMING LI,1,2 CHAOKE LIANG, 3CHARLES W.
SLEMENDA,4,5 RONGDI JI, SHUZHUANG SUN,3 JINGXIANG CAO, 3CHRISTINE L. EMSLEY,4 FENG MA, YUNPENG WU, 3PO YING, YAN ZHANG,4 SUJUAN GAO, 4WU ZHANG,1 BARRY P. KATZ, SHIRU NIU,3 SHOUREN CAO,3 and CONRAD C. JOHNSTON Jr4. Genetic factors influence the effects of fluoride (F) on amelogenesis and bone homeostasis but the underlying molecular mechanisms remain undefined.
A label-free proteomics approach was employed to identify and evaluate changes in bone protein expression in two mouse strains having different susceptibilities to develop dental fluorosis and to alter bone by: Introduction Chronic exposure to combined fluoride and arsenic continue to be a major public health problem worldwide.
Although there have been reports in the literature about the toxicity of arsenic and fluoride individually, there is very little known about the combined effects of these two elements. In this study, based on the population and in vivo, the aim is to explore the combined bone Cited by: 2.
Exposure of plants to airborne fluorides leads to deposition on the outer surface and uptake into plant tissues.
Fluoride in vegetation contributes to human and animal dietary fluoride. Long-term exposure to concentrations of more than µg/m3 may cause injury to plants (3).
Fluoride Exposure and Risk of Bone Fracture 53 at 75 mg per day in both trials, and patients received mg of calcium daily in addition to sodium fluoride or placebos. Riggs et al. () reported data from a 4-year trial of randomized patients with osteoporosis and vertebral fractures.
Fluoride exposure has increased due to water fluoridation, dental materials, & other fluoridated products that are accompanied by human health risksAuthor: Randall Moore. How Fluoride Causes Bone Loss. Fluorine activates both osteoblasts (bone-building cells) and osteoclasts (bone-resorbing cells).
While fluoride may increase bone mass, the newly formed bone lacks normal structure and strength. Under a microscope, the “crystallization pattern” of bone from fluoride-treated animals and humans proves abnormal.Various researchers’ study came to a point that insulin resistance in humans caused by chronic fluoride exposure from drinking water .
According to The US National Research Council [ 10 ], impaired glucose metabolism appears to be associated with serum or plasma fluoride concentrations of about ppm or greater in both animals and Cited by: